By Denson G. Fujikawa (auth.), Denson G. Fujikawa (eds.)
This ebook is the results of a convergence of clinical information about mechanisms that produce acute nerve phone loss of life within the mind. even supposing likely disparate, stroke, mind and spinal wire trauma, coma from a low serum glucose focus (hypoglycemia), and lengthy epileptic seizures have in universal the inciting issue of excitotoxicity, the activation of a particular subtype of glutamate receptor through an increased extracellular glutamate focus that leads to an over the top inflow of calcium into nerve cells. The excessive calcium focus in nerve cells prompts a number of enzymes which are accountable for degradation of cytoplasmic proteins and cleavage of nuclear DNA, leading to nerve cellphone demise. The excessive calcium focus additionally interferes with mitochondrial breathing, with the ensuing creation of loose radicals that harm mobile membranes and nuclear DNA. knowing the biochemical pathways that produce nerve mobilephone demise is step one towards devising an efficient neuroprotective process, the final word goal.
Acute Neuronal harm should be necessary to neuroscientists and basic phone biologists attracted to telephone demise. The ebook can also be useful to clinically orientated neuroscientists, together with neurologists, neurosurgeons and psychiatrists.
About the Editor:
Dr. Denson Fujikawa is an accessory Professor of Neurology on the David Geffen college of drugs at UCLA, a member of the mind learn Institute at UCLA and a employees Neurologist on the division of Veterans Affairs better l. a. Healthcare method. His curiosity in mechanisms of nerve mobile demise within the mind begun in the course of a two-year epilepsy study fellowship with Dr. Claude Wasterlain, from 1981 to 1983. he's a Fellow of the yank Academy of Neurology and is a member of the yank Epilepsy Society, American Neurological organization, foreign Society for Cerebral Blood circulate and Metabolism, and the Society for Neuroscience.
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Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms by Denson G. Fujikawa (auth.), Denson G. Fujikawa (eds.)